Biological fabrication of zinc oxide nanoparticles from <i>Nepeta cataria</i> potentially produces apoptosis through inhibition of proliferative markers in ovarian cancer

Abstract This study evaluated the biological fabrication and characterization of zinc oxide nanoparticles (ZnONPs) using Nepeta cataria (NC) their anticancer activity against ovarian cancer cells (SKOV3). synthesized ZnONPs leaf extract N. through a method. The particles were characterized in several ways such as zeta potential, ultraviolet-visible (UV-Vis) spectrum, Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), scanning electron microscopic (SEM) analysis. UV-Vis spectrum exhibited that maximum spectra found to be 380 nm. size material was shown 75.9 nm confirmed by dynamic light scattering measurement. Moreover, XRD, SEM, transmission analysis materials crystal-based ZnONPs. FTIR studies represent biologically active functional groups existed nanoparticles. In addition, ability inhibitory role ZnONPs-NC SKOV3 investigated. We causes efficient toxicity increasing cytotoxicity depending on reactive oxygen species production nuclear fragmentation cells. activates Bax Caspases while inhibiting Bcl-2 proteins Furthermore, we discovered inhibits proliferative markers PCNA, cyclin-D1, matrix metallo proteinase (MMP)-2, MMP-9) Thus, effectively cell growth.